|
X-linked centronuclear myopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in the protein responsible for X-linked myotubular myopathy (myotubularin, MTM1) also induced NFL abnormalities in these cells.
|
17973976 |
2008 |
|
Wallerian Degeneration
|
0.200 |
Biomarker
|
phenotype |
RGD |
Selective solubilization of high-molecular-mass neurofilament subunit during nerve regeneration.
|
10646539 |
2000 |
|
Waddling gait
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Variable expressivity
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Unipolar Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Treatment resistance in major depression is correlated with increased plasma levels of neurofilament light protein reflecting axonal damage.
|
31088642 |
2019 |
|
Unipolar Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed.
|
16023328 |
2005 |
|
Unipolar Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In particular, we found decreased NF-L, PSD95, and SAP102 transcripts in bipolar disorder, and decreased SAP102 levels in major depression.
|
15054476 |
2004 |
|
Ulnar claw
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The results show that the expression of NEFL induces cancer cell apoptosis and inhibits invasion in these cell lines, suggesting that NEFL may play a role in cancer cell apoptosis and invasion.
|
23992471 |
2014 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, NEFL-siRNA could significantly attenuate the inhibitory effects of knockdown miR-183 on the proliferation and invasion of U251 cells via mTOR signaling pathway.
|
26879754 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, via the mTOR signaling pathway, NEFL-siRNA could significantly attenuate the inhibitory effects of knockdown miR-25 on the proliferation and invasion of U251 cells.
|
26209061 |
2015 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our studies suggest that NEFL methylation is a novel mechanism for NSCLC invasion and metastasis and that NEFL may represent a candidate biomarker for recurrence and survival in patients with NSCLC.
|
26801564 |
2016 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Effects of brain ischemia on intermediate filaments of rat hippocampus.
|
8726968 |
1996 |
|
Tauopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Using Western Blot and ELISA we characterized NF-L and disease-related proteins in brain, CSF and plasma samples from Tg4510 mice (tauopathy/AD), MitoPark mice (PD), and their age-matched control littermates.
|
28461218 |
2017 |
|
Talipes cavus
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Subependymal Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunoreactivity for HOXB13, NEFL and PDGFR alpha was strongest in MEPN and virtually absent in subependymoma.
|
19793339 |
2010 |
|
Subcortical Vascular Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total tau (T-tau), amyloid beta 1-42 (Abeta(42)) and neurofilament light (NF-L) in patients with MCI could predict subcortical vascular dementia (SVD) and Alzheimer's disease (AD) at follow-up.
|
19864909 |
2009 |
|
Subarachnoid Hemorrhage
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seizures, CSF neurofilament light and tau in patients with subarachnoid haemorrhage.
|
29164612 |
2018 |
|
Subarachnoid Hemorrhage
|
0.020 |
Biomarker
|
disease |
BEFREE |
Plasma Neurofilament Light Chain Is Associated with Poor Functional Outcome and Mortality Rate After Spontaneous Subarachnoid Hemorrhage.
|
31808039 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of NEFL in cell growth and invasion in head and neck squamous cell carcinoma cell lines.
|
23992471 |
2014 |
|
Spinal Muscular Atrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Neurofilament light chain in serum of adolescent and adult SMA patients under treatment with nusinersen.
|
31552549 |
2020 |
|
Spinal Muscular Atrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
NfL, protein and quotients of albumin (Q<sub>alb</sub>) increased slightly in SMA patients after the fourth injection.
|
31205491 |
2019 |
|
Spinal Muscular Atrophy
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Baseline levels of NFL (4598 ± 981 vs 148 ± 39, P = 0.001), tau (939 ± 159 vs 404 ± 86, P = 0.02), and GFAP (236 ± 44 vs 108 ± 26, P = 0.02) were significantly higher in SMA children than controls.
|
31123861 |
2019 |
|
Spastic Paraplegia, Hereditary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum neurofilament light chain is increased in hereditary spastic paraplegias.
|
30009206 |
2018 |
|
Snowflake vitreoretinal degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
A combination of the biomarkers Abeta(42), T-tau, P-tau(181) and NF-L has the potential to improve the clinical separation of MCI-SVD patients from stable MCI and MCI-AD patients.
|
19864909 |
2009 |